A modified calcium retention capacity assay clarifies the roles of extra- and intracellular calcium pools in mitochondrial permeability transition pore opening

Archive ouverte

Harisseh, Rania | Abrial, Maryline | Chiari, Pascal | Al-Mawla, Ribal | Villedieu, Camille | Tessier, Nolwenn | Bidaux, Gabriel | Ovize, Michel | Gharib, Abdallah

Edité par CCSD ; American Society for Biochemistry and Molecular Biology -

International audience. The abbreviations used are: SERCA, sarco/endoplasmic Ca 2ϩ ATPase; CRC, Ca 2ϩ retention capacity; AR, anoxia-reoxygenation; mPTP, mitochondria permeability transition pore; CsA, cyclosporine A; CypD, cyclophilin D; CICR, Ca 2ϩ-induced Ca 2ϩ release; FCCP, carbonyl cyanide p-trifluoromethoxyphenylhydrazone; A.U., arbitrary unit(s); ANOVA, analysis of variance. cro tapraid4/zbc-bc/zbc-bc/zbc99919/zbc1234-19z ZSUBMIT 11 xppws Sϭ3 10/9/19 4:07 4/Color Figure(s) F1-5

Suggestions

Du même auteur

Cyclophilin D modulates the cardiac mitochondrial target of isoflurane, sevoflurane, and desflurane

Archive ouverte | Harisseh, Rania | CCSD

Background: Volatile anesthetics are known to limit myocardial ischemia-reperfusion injuries. Mitochondria were shown to be major contributors to cardioprotection. Cyclophilin D (CypD) is one of the main regulators of mitochondria...

Involvement of Cyclophilin D and Calcium in Isoflurane-induced Preconditioning

Archive ouverte | Teixeira, Geoffrey | CCSD

International audience

Acute Induction of Translocon-Mediated Ca2+ Leak Protects Cardiomyocytes Against Ischemia/Reperfusion Injury

Archive ouverte | Al-Mawla, Ribal | CCSD

International audience. During myocardial infarction, dysregulation of Ca 2+ homeostasis between the reticulum, mitochondria, and cytosol occurs in cardiomyocytes and leads to cell death. Ca 2+ leak channels are tho...

Chargement des enrichissements...