Internal dosimetry of [$^{99m}$Tc]NTP15‐5 radiotracer for cartilage imaging in preclinical and clinical models using the GATE Monte Carlo platform

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Rosa Fois, Giovanna | Valla, Clémence | Jouberton, Elodie | Sas, Nicolas | Billoux, Tommy | Auzeloux, Philippe | Cachin, Florent | Miot-Noirault, Elisabeth | Maigne, Lydia

Edité par CCSD ; American Association of Physicists in Medicine -

International audience. This study aims to perform dosimetry for [99m Tc]NTP15-5 radiotracer used in imaging of articular cartilage in rabbits and humans. The radiotracer (covered by a world patent WO 01/00621 A1) has been proposed in the past years for the study of cartilage in osteoarthritis diseases. A sensitive imaging approach is essential to quantify osteoarthritis progression and monitor response to new therapies. [99m Tc]NTP15-5 binds to cartilage proteoglycans whose decreased content is associated to a loss of biomedical function of cartilage. We have implemented the whole dosimetry study concerning this new radiotracer for rabbits and humans using the GATE Monte Carlo platform.

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