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A novel view on the role of intracellular tails in surface delivery of the potassium-chloride cotransporter KCC2

Archive ouverte | Friedel, Perrine | CCSD

International audience. A plethora of neurological disorders are associated with alterations in the expression and localization of potassium-chloride cotransporter type 2 (KCC2), making KCC2 a critical player in neu...

Hydrogenated diglucose detergents for membrane-protein extraction and stabilization

Archive ouverte | Guillet, Pierre | CCSD

International audience. We report herein the design and synthesis of a novel series of alkyl glycosides detergents consisting of a nonionic polar headgroup that comprises two glucose moieties in a branched arrangeme...

Quantification of Detergents Complexed with Membrane Proteins

Archive ouverte | Chaptal, Vincent | CCSD

International audience. Most membrane proteins studies require the use of detergents, but because of the lack of a general, accurate and rapid method to quantify them, many uncertainties remain that hamper proper fu...

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