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A centriolar lifeline

Archive ouverte | Gemble, Simon | CCSD

International audience. Ploidy variations such as genome doubling are frequent in human tumors and have been associated with genetic instability favoring tumor progression. How polyploid cells deal with increased ce...

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Archive ouverte | Goupil, Alix | CCSD

International audience. Ploidy variations such as genome doubling are frequent in human tumors and have been associated with genetic instability favoring tumor progression. How polyploid cells deal with increased ce...

Plk4 Regulates Centriole Asymmetry and Spindle Orientation in Neural Stem Cells

Archive ouverte | Gambarotto, Davide | CCSD

International audience. Defects in mitotic spindle orientation (MSO) disrupt the organization of stem cell niches impacting tissue morphogenesis and homeostasis. Mutations in centrosome genes reduce MSO fidelity, le...

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