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Identification of a pH-Sensitive Switch in VSV-G and a Crystal Structure of the G Pre-fusion State Highlight the VSV-G Structural Transition Pathway

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Beilstein, Frauke | Abou Hamdan, Abbas | Raux, Hélène | Belot, Laura | Ouldali, Malika | Albertini, Aurélie | Gaudin, Yves

Edité par CCSD ; Elsevier Inc -

International audience. Highlights d A VSV-G pre-fusion crystal structure reveals its C-terminal part organization d H407A mutation affects G fusion properties by destabilizing the G pre-fusion state d Mutants L396I and S422I compensate H407A by stabilizing the G pre-fusion state d G structural transition is initiated in the C-terminal part of the ectodomain

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