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Higher Anti-Tumor Efficacy of the Dual HER3-EGFR Antibody MEHD7945a Combined with Ionizing Irradiation in Cervical Cancer Cells

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Bourillon, Laura | Demontoy, Sylvain | Lenglet, Alexis | Zampieri, Alexandre | Fraisse, Julien | Jarlier, Marta | Boissière-Michot, Florence | Perrochia, Hélène | Rathat, Gauthier | Garambois, Véronique | Bonnefoy, Nathalie | Michaud, Henri-Alexandre | Chardès, Thierry | Tosi, Diego | Pèlegrin, André | Azria, David | Larbouret, Christel | Bourgier, Céline

Edité par CCSD ; Elsevier -

International audience. Targeting EGFR and HER3 with a specific dual antibody (MEHD7945A) enhanced irradiation efficacy in vitro (cervical cancer cell lines) and in vivo (xenografted mice) in an additive way. Moreover, our study suggests that co-expression of EGFR and HER3 could be a candidate prognostic biomarker of poor overall survival in patients with cervical cancer. These preliminary results should be confirmed in a study with a larger sample.

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