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The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled

Archive ouverte | Kratzer, Marie-Claire | CCSD

Directional migration during embryogenesis and tumor progression faces the challenge that numerous external signals need to converge to precisely control cell movement. The Rho guanine exchange factor (GEF) Trio is especially well...

ADAM13 cleavage of cadherin-11 promotes CNC migration independently of the homophilic binding site

Archive ouverte | Abbruzzese, G | CCSD

The cranial neural crest (CNC) is a highly motile population of cells that is responsible for forming the face and jaw in all vertebrates and perturbing their migration can lead to craniofacial birth defects. Cell motility require...

Cadherin-11 localizes to focal adhesions and promotes cell-substrate adhesion

Archive ouverte | Langhe, R. P. | CCSD

Cadherin receptors have a well-established role in cell-cell adhesion, cell polarization and differentiation. However, some cadherins also promote cell and tissue movement during embryonic development and tumour progression. In pa...

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