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Killer cell immunoglobulin–like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1

Archive ouverte | Martin, Maureen | CCSD

International audience. HLA-B*57 control of HIV involves enhanced CD8+ T cell responses against infected cells, but extensive heterogeneity exists in the level of HIV control among B*57+ individuals. Using whole-gen...

Dysregulated Tim-3 expression on natural killer cells is associated with increased Galectin-9 levels in HIV-1 infection

Archive ouverte | Jost, Stephanie | CCSD

International audience. Natural killer (NK) cells constitutively express high levels of Tim-3, an immunoregulatory molecule recently proposed to be a marker for mature and functional NK cells. Whether HIV-1 infectio...

Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities

Archive ouverte | Leitman, Ellen | CCSD

International audience. Antigen-specific T-cells are highly variable, spanning potent antiviral efficacy and damaging auto-reactivity. In virus infections, identifying the most efficacious responses is critical to v...

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