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HSP110 translocates to the nucleus upon genotoxic chemotherapy and promotes DNA repair in colorectal cancer cells

Archive ouverte | Causse, Sébastien | CCSD

International audience. A multicenter clinical study demonstrated the presence of a loss-of-function HSP110 mutation in about 15% of colorectal cancers, which resulted from an alternative splicing and was produced a...

Selecting the first chemical molecule inhibitor of HSP110 for colorectal cancer therapy

Archive ouverte | Gozzi, Gustavo J. | CCSD

indexation en cours.. International audience. Pro-survival stress-inducible chaperone HSP110 is the only HSP for which a mutation has been found in a cancer. Multicenter clinical studies demonstrated a direct associ...

Lactobacillus stress protein GroEL prevents colonic inflammation

Archive ouverte | Dias, Alexandre | CCSD

International audience. BACKGROUND: We previously showed that supernatants of Lactobacillus biofilms induced an anti-inflammatory response by affecting the secretion of macrophage-derived cytokines, which was abroga...

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