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Unravelling ceftazidime/avibactam resistance of KPC-28, a KPC-2 variant lacking carbapenemase activity

Archive ouverte | Oueslati, Saoussen | CCSD

International audience. BACKGROUND: KPC-like carbapenemases have spread worldwide with more than 30 variants identified that differ by single or double amino-acid substitutions.OBJECTIVES: To describe the steady-sta...

Beta-lactamase database (BLDB) – structure and function

Archive ouverte | Naas, Thierry | CCSD

International audience. Beta-Lactamase Database (BLDB) is a comprehensive, manually curated public resource providing up-to-date structural and functional information focused on this superfamily of enzymes with a gr...

Biochemical and Structural Characterization of OXA-405, an OXA-48 Variant with Extended-Spectrum β-Lactamase Activity

Archive ouverte | Oueslati, Saoussen | CCSD

International audience. OXA-48-producing Enterobacterales have now widely disseminated globally. A sign of their extensive spread is the identification of an increasing number of OXA-48 variants. Among them, three a...

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