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Glycan chains of Prion protein PrPc affect its metal ion-binding-activity

Archive ouverte | Moudjou, Mohammed, M. | CCSD

International audience. PrPc is the normal isoform of the prion protein PrP, which can be converted into PrPsc, the pathology-associated conformer in TSE. PrPc contains two N-linked glycan chains located on the C-pr...

Etude des maladies à Prions: exemple de la tremblante du mouton

Archive ouverte | Moudjou, Mohammed, M. | CCSD

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Glycan chains modulate prion protein binding to immobilized metal ions

Archive ouverte | Moudjou, Mohammed, M. | CCSD

International audience. PrPc is the normal isoform of the prion protein which can be converted into PrPSc, the pathology-associated conformer in prion diseases. It contains two N-linked glycan chains attached to the...

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