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PB1-F2 Influenza A Virus Protein Adopts a beta-Sheet Conformation and Forms Amyloid Fibers in Membrane Environments

Archive ouverte | Chevalier, Christophe | CCSD

International audience. The influenza A virus PB1-F2 protein, encoded by an alternative reading frame in the PB1 polymerase gene, displays a high sequence polymorphism and is reported to contribute to viral pathogen...

Oligomerization paths of the nucleoprotein of influenza A virus

Archive ouverte | Tarus, Bogdan | CCSD

International audience. The influenza viruses contain a segmented, negative strand RNA genome. Each RNA segment is covered by multiple copies of the Nucleoprotein (NP) and is associated with the polymerase complex i...

Influenza A Virus Protein PB1-F2 Exacerbates IFN-β Expression of Human Respiratory Epithelial Cells

Archive ouverte | Le Goffic, Ronan | CCSD

International audience. Abstract The PB1-F2 protein of the influenza A virus (IAV) contributes to viral pathogenesis by a mechanism that is not well understood. PB1-F2 was shown to modulate apoptosis and to be targe...

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