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Characterisation of monoclonal antibodies discriminating the glycoforms and alleles of the sheep prion protein. Approche immunochimique de la structure de la protéine cellulaire PrPc ovine. Caractérisation d’anticorps discriminant les glycoformes et les allèles de la protéine Prion chez le mouton

Archive ouverte | Moudjou, Mohammed, M. | CCSD

National audience. Transmissible spongiform encephalopathies (TSE)are fatal neurodegenerative diseases characterised bythe accumulation in the brain of an abnormal form ofthe host PrP protein. PrP is a cell surface ...

Glycan chains modulate prion protein binding to immobilized metal ions

Archive ouverte | Moudjou, Mohammed, M. | CCSD

International audience. PrPc is the normal isoform of the prion protein which can be converted into PrPSc, the pathology-associated conformer in prion diseases. It contains two N-linked glycan chains attached to the...

Plasminogen-based capture combined with amplification technology for the detection of PrP(TSE) in the pre-clinical phase of infection

Archive ouverte | Segarra, Christiane | CCSD

International audience. Background: Variant Creutzfeldt-Jakob disease (vCJD) is a neurodegenerative infectious disorder, characterized by a prominent accumulation of pathological isoforms of the prion protein (PrPTS...

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