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Characterization of the contribution of buccal absorption to internal exposure to bisphenol A through the diet

Archive ouverte | Guignard, Davy | CCSD

International audience. The gavage route is often used for the toxicological evaluation of food contaminants. This route does not take into account absorption of the toxicants through the buccal mucosa, as evidenced...

Evidence for bisphenol A-induced disruption of maternal thyroid homeostasis in the pregnant ewe at low level representative of human exposure

Archive ouverte | Guignard, Davy | CCSD

Many uncertainties remain regarding the potential of bisphenol A (BPA) as a thyroid disruptor in mammals and the relevance of experimental data to humans. The relevance of the exposure schemes used in experimental in vivo studies ...

Bisphenol A glucuronide deconjugation is a determining factor of fetal exposure to bisphenol A.

Archive ouverte | Gauderat, Glenn | CCSD

International audience. Previous studies in experimental animals have shown that maternal exposure to bisphenol A (BPA) during late pregnancy leads to high plasma concentrations of BPA glucuronide (BPAG) in fetus co...

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