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Human papillomavirus type 18 E6 protein binds the cellular PDZ protein TIP-2/GIPC, which is involved in transforming growth factor beta signaling and triggers its degradation by the proteasome.

Archive ouverte | Favre-Bonvin, Arnaud | CCSD

Several viral proteins expressed by DNA or RNA transforming viruses have the particular property of binding via their C-terminal end to various cellular proteins with PDZ domains. This study is focused on the PDZ protein TIP-2/GIP...

Identification of functional PDZ domain binding sites in several human proteins

Archive ouverte | Fabre, Stéphane | CCSD

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The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins

Archive ouverte | Rousset, Raphaël | CCSD

International audience

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