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The genotoxin Colibactin exacerbates lymphopenia and decreases survival rate in mice infected with septicemic Escherichia coli

Archive ouverte | Marcq, Ingrid | CCSD

International audience. Sepsis is a life-threatening infection. Escherichia coli is the first known cause of bacteremia leading to sepsis. Lymphopenia was shown to predict bacteremia better than conventional markers...

Maternally acquired genotoxic Escherichia coli alters offspring's intestinal homeostasis

Archive ouverte | Payros, Delphine | CCSD

International audience. The neonatal gut is rapidly colonized by a newly dominant group of commensal Escherichia coli strains among which a large proportion produces a genotoxin called colibactin. In order to analyz...

Genotoxicity of Escherichia coli Nissle 1917 strain cannot be dissociated from its probiotic activity

Archive ouverte | Olier, Maïwenn | CCSD

International audience. Oral administration of the probiotic bacterium Escherichia coli Nissle 1917 improves chronic inflammatory bowel diseases, but the molecular basis for this therapeutic efficacy is unknown. E. ...

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