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In vivo activities of recombinant divercin V41 and its structural variants against Listeria monocytogenes

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Rihakova, Jitka | Cappelier, Jean-Michel | Hue, Isabelle | Demnerova, Katerina | Federighi, Michel, M. | Prévost, Herve, H. | Drider, Djamel

Edité par CCSD ; American Society for Microbiology -

International audience. Recombinant divercin RV41 (DvnRV41) and its structural variants were used in this study to assess their antilisterial activities in vivo in mice challenged intravenously with Listeria monocytogenes EGDe. Treatment with DvnRV41 before and after infection permitted a conclusion as to the capacities of this peptide to retain activity and reduce growth of L. monocytogenes EGDe. Moreover, the use of structural variants for the first time in vivo and the reductions of their activities confirmed the importance of certain amino acids in antilisterial activity.

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