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Glucocorticoid receptor in astrocytes regulates midbrain dopamine neurodegeneration through connexin hemichannel activity

Archive ouverte | Maatouk, Layal | CCSD

International audience. The precise contribution of astrocytes in neuroinflammatory process occurring in Parkinson’s disease (PD) is not well characterized. In this study, using GRCx30CreERT2 mice that are condition...

Contribution of Astroglial Cx43 Hemichannels to the Modulation of Glutamatergic Currents by D-Serine in the Mouse Prefrontal Cortex

Archive ouverte | Meunier, Claire | CCSD

International audience. Astrocytes interact dynamically with neurons by modifying synaptic activity and plasticity. This interplay occurs through a process named gliotransmission, meaning that neuroactive molecules ...

Proinflammatory cytokines released from microglia inhibit gap junctions in astrocytes: potentiation by β-amyloid

Archive ouverte | Même, William | CCSD

International audience. Brain inflammation is characterized by a reactive gliosis involving the activation of astrocytes and microglia. This process, common to many brain injuries and diseases, underlies important p...

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