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Dimorphic metabolic and endocrine disorders in mice lacking the constitutive androstane receptor

Archive ouverte | Lukowicz, Céline | CCSD

International audience. Metabolic diseases such as obesity, type II diabetes and hepatic steatosis are a public health concern in developed countries. The metabolic risk is gender-dependent. The constitutive androst...

The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice

Archive ouverte | Barretto, Sharon | CCSD

International audience. Background: The gut microbiota-intestine-liver relationship is emerging as an important factor in multiple hepatic pathologies, but the hepatic sensors and effectors of microbial signals are ...

Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target

Archive ouverte | Smati, Sarra | CCSD

International audience. Objective We evaluated the influence of sex on the pathophysiology of non-alcoholic fatty liver disease (NAFLD). We investigated diet-induced phenotypic responses to define sex-specific regul...

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