Turning off Bacillus cereus quorum sensing system with peptidic analogs

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Yehuda, Avishag | Slamti, Leyla | Bochnik-Tamir, Racheli | Malach, Einav | Lereclus, Didier | Hayouka, Zvi

Edité par CCSD ; Royal Society of Chemistry -

International audience. We explored quenching of the PlcR-PapR quorum-sensing system in Bacillus cereus. We generated PapR(7)-peptidic derivatives that inhibit this system and thus the production of virulence factors, reflected by a loss in hemolytic activity, without affecting bacterial growth. To our knowledge, these peptides represent the first potent synthetic inhibitors of quorum-sensing in B. cereus.

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