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Miniaturized weak affinity chromatography for ligand identification of nanodiscs-embedded G-protein coupled receptors

Archive ouverte | Lecas, Lucile | CCSD

International audience. Biophysical techniques that enable the screening and identification of weak affinity fragments against a target protein are at the heart of Fragment Based Drug Design approaches. In the case ...

In situ characterization of antibody grafting on porous monolithic supports

Archive ouverte | Faye, Clément | CCSD

International audience. The efficient immobilization of antibodies on monolithic support is one of the most critical steps when preparing immunoaffinity supports. In this work, the ADECA (amino density estimation by...

Ligand Screening of Membrane Proteins Embedded in Nanodiscs: How to Manage Non-Specific Interactions in Weak Affinity Chromatography?

Archive ouverte | Vidal, François-Xavier | CCSD

International audience. Miniaturized weak affinity chromatography is emerging as an interesting alternative to conventional biophysical tools for performing fragment-screening studies in the context of fragment-base...

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