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R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways

Archive ouverte | Lacour, Floriane | CCSD

International audience. Using mice lacking the Wnt enhancer Rspo1, Lacour et al. demonstrate that Rspo1 controls muscle cell fusion during skeletal muscle regeneration. Rspo1-null muscle progenitor cells differentia...

Aging disrupts muscle stem cell function by impairing matricellular WISP1 secretion from fibro-adipogenic progenitors

Archive ouverte | Lukjanenko, Laura | CCSD

International audience. Research on age-related regenerative failure of skeletal muscle has extensively focused on the phenotypes of muscle stem cells (MuSCs). In contrast, the impact of aging on regulatory cells in...

Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development

Archive ouverte | Vaughan, Danielle | CCSD

International audience. Numerous approaches are being developed to promote post-natal muscle growth based on attenuating Myostatin/Activin signalling for clinical uses such as the treatment neuromuscular diseases, c...

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