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Osteoblastic heparan sulfate glycosaminoglycans control bone remodeling by regulating Wnt signaling and the crosstalk between bone surface and marrow cells

Archive ouverte | Mansouri, Rafik | CCSD

International audience. Stimulating bone formation is an important challenge for bone anabolism in osteoporotic patients or to repair bone defects. The osteogenic properties of matrix glycosaminoglycans (GAGs) have ...

N-Cadherin Interacts with Axin and LRP5 To Negatively Regulate Wnt/ -Catenin Signaling, Osteoblast Function, and Bone Formation

Archive ouverte | Hay, Eric | CCSD

International audience. Wnt signaling plays an important role in the regulation of bone formation and bone mass. The mechanisms that regulate canonical Wnt signaling in osteoblasts are not fully understood. We show ...

RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. : RhoA mediates osteosarcoma cell apoptosis

Archive ouverte | Fromigue, Olivia | CCSD

Osteosarcoma is the most common primary bone tumour in young adults. Despite improved prognosis, resistance to chemotherapy remains responsible for failure of osteosarcoma treatment. The identification of signals that promote apop...

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