Afficher la couverture 'Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors | Gottar, Marie' en grand format
/5

0 avis

Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors

Archive ouverte

Gottar, Marie | Gobert, Vanessa | Matskevich, Alexey | Reichhart, Jean-Marc | Wang, Chengshu | Butt, Tariq | Belvin, Marcia | Hoffmann, Jules, A. | Ferrandon, Dominique

Edité par CCSD ; Elsevier -

International audience. The Drosophila immune system discriminates between various types of infections and activates appropriate signal transduction pathways to combat the invading microorganisms. The Toll pathway is required for the host response against fungal and most Gram-positive bacterial infections. The sensing of Gram-positive bacteria is mediated by the pattern recognition receptors PGRP-SA and GNBP1 that cooperate to detect the presence of infections in the host. Here, we report that GNBP3 is a pattern recognition receptor that is required for the detection of fungal cell wall components. Strikingly, we find that there is a second, parallel pathway acting jointly with GNBP3. The Drosophila Persephone protease activates the Toll pathway when proteolytically matured by the secreted fungal virulence factor PR1. Thus, the detection of fungal infections in Drosophila relies both on the recognition of invariant microbial patterns and on monitoring the effects of virulence factors on the host.

Consulter en ligne

Suggestions

Du même auteur

Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors

Archive ouverte | Gobert, Vanessa | CCSD

International audience. The Toll-dependent defense against Gram-positive bacterial infections in Drosophila is mediated through the peptidoglycan recognition protein SA (PGRP-SA). A mutation termed osiris disrupts t...

Dual activation of the Drosophila toll pathway by two pattern recognition receptors

Archive ouverte | Gobert, Vanessa | CCSD

The Toll- dependent defense against Gram-positive bacterial infections in Drosophila is mediated through the peptidoglycan recognition protein SA (PGRP-SA). A mutation termed osiris disrupts the Gram-negative binding protein 1 ( G...

The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein

Archive ouverte | Gottar, Marie | CCSD

International audience. The antimicrobial defence of Drosophila relies largely on the challenge-induced synthesis of an array of potent antimicrobial peptides by the fat body. The defence against Gram-positive bacte...

Chargement des enrichissements...