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Time-resolved FRET binding assay to investigate hetero-oligomer binding properties: proof of concept with dopamine D1/D3 heterodimer

Archive ouverte | Hounsou, Candide | CCSD

International audience. G protein-coupled receptors (GPCRs) have been described to form hetero-oligomers. The importance of these complexes in physiology and pathology is considered crucial, and heterodimers represe...

Time-Resolved FRET Strategy to Screen GPCR Ligand Library

Archive ouverte | Oueslati, Nadia | CCSD

International audience. Screening chemical libraries to find specific drugs for G protein-coupled receptors is still of major interest. Indeed, because of their major roles in all physiological functions, G protein-...

Time-resolved FRET based assays to characterize hetero-oligomer pharmacology

Archive ouverte | Heuninck, Joyce | CCSD

International audience. Although G protein-coupled receptor (GPCR) oligomerization is a matter of debate, it has been shown that the nature of the GPCR partners within the oligomers can influence the pharmacological...

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