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Cardiac iron overload in chronically transfused patients with thalassemia, sickle cell anemia, or myelodysplastic syndrome

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de Montalembert, Mariane | Ribeil, Jean-Antoine | Brousse, Valentine | Guerci-Bresler, Agnès | Stamatoullas, Aspasia | Vannier, Jean-Pierre | Dumesnil, Cécile | Lahary, Agnès | Touati, Mohamed | Bouabdallah, Krimo | Cavazzana, Marina | Chauzit, Emmanuelle | Baptiste, Amandine | Lefebvre, Thibaud | Puy, Hervé | Elie, Caroline | Karim, Zoubida | Ernst, Olivier | Rose, Christian

Edité par CCSD ; Public Library of Science -

International audience. was low in thalassemia, normal in SCA, and markedly elevated in MDS (P<0.001). Two mechanisms may explain that iron deposition largely spares the heart in SCA: the high level of erythropoiesis recycles the iron and the chronic inflammation retains iron within the macrophages. Thalassemia, in contrast, is characterized by inefficient erythropoiesis, unable to handle free iron. Iron accumulation varies widely in MDS syndromes due to the competing influences of abnormal erythropoiesis, excess iron supply, and inflammation.

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