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Two HIRA-dependent pathways mediate H3.3 de novo deposition and recycling during transcription. Deux voies dépendantes de l'HIRA assurent la médiation du dépôt et du recyclage de novo du H3.3 pendant la transcription

Archive ouverte | Torné, Júlia | CCSD

International audience. Nucleosomes represent a challenge in regard to transcription. Histone eviction enables RNA polymerase II (RNAPII) progression through DNA, but compromises chromatin integrity. Here, we used t...

High-resolution visualization of H3 variants during replication reveals their controlled recycling

Archive ouverte | Clement, Camille | CCSD

International audience. DNA replication is a challenge for the faithful transmission of parental information to daughter cells, as both DNA and chromatin organization must be duplicated. Replication stress further c...

Regulation of replicative histone RNA metabolism by the histone chaperone ASF1

Archive ouverte | Mendiratta, Shweta | CCSD

International audience. In S phase, duplicating and assembling the whole genome into chromatin requires upregulation of replicative histone gene expression. Here, we explored how histone chaperones control histone p...

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