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Lysosomal degradation of newly formed insulin granules contributes to beta cell failure in diabetes

Archive ouverte | Pasquier, Adrien | CCSD

Compromised function of insulin-secreting pancreatic beta cells is central to the development and progression of Type 2 Diabetes (T2D). However, the mechanisms underlying beta cell failure remain incompletely understood. Here, we ...

Liver ubiquitome uncovers nutrient-stress-mediated trafficking and secretion of complement C3

Archive ouverte | Magliarelli, Helena de Fatima | CCSD

International audience. Adaptation to changes in nutrient availability is crucial for cells and organisms. Posttranslational modifications of signaling proteins are very dynamic and are therefore key to promptly res...

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

Archive ouverte | Zhang, Zhirong | CCSD

PMC5584123. The inflammasomes are multiprotein complexes sensing tissue damage and infectious agents to initiate innate immune responses. Different inflammasomes containing distinct sensor molecules exist. The NLRP3...

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