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Myosin VI deafness mutation prevents the initiation of processive runs on actin

Archive ouverte | Pylypenko, Olena | CCSD

International audience. Mutations in the reverse-direction myosin, myosin VI, are associated with deafness in humans and mice. A myosin VI deafness mutation, D179Y, which is in the transducer of the motor, uncoupled...

The myosin X motor is optimized for movement on actin bundles

Archive ouverte | Ropars, Virginie | CCSD

International audience. Myosin X has features not found in other myosins. Its structure must underlie its unique ability to generate filopodia, which are essential for neuritogenesis, wound healing, cancer metastasi...

Role of Insert-1 of Myosin VI in Modulating Nucleotide Affinity

Archive ouverte | Pylypenko, Olena | CCSD

International audience. Myosin VI is unique in its directionality among myosin superfamily members and also displays a slow and strain-dependent rate of ATP binding that allows for gating between its heads. In this ...

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