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Myosin 7 and its adaptors link cadherins to actin

Archive ouverte | Yu, I-Mei | CCSD

International audience. Cadherin linkages between adjacent stereocilia and microvilli are essential for mechanotransduction and maintaining their organization. They are anchored to actin through interaction of their...

Circularly permuted fluorogenic proteins for the design of modular biosensors

Archive ouverte | Tebo, Alison, G | CCSD

International audience. Fluorescent reporters are essential components for the design of optical biosensors that are able to image intracellular analytes in living cells. Herein, we describe the development of circu...

Nucleotide-free structures of KIF20A illuminate atypical mechanochemistry in this kinesin-6

Archive ouverte | Ranaivoson, Fanomezana Moutse | CCSD

International audience. KIF20A is a critical kinesin for cell division and a promising anti-cancer drug target. The mechanisms underlying its cellular roles remain elusive. Interestingly, unusual coupling between th...

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