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Molecular organization and dynamics of the melatonin MT1 receptor/RGS20/Gi protein complex reveal asymmetry of receptor dimers for RGS and Gi coupling

Archive ouverte | Maurice, Pascal | CCSD

International audience. Functional asymmetry of G-protein-coupled receptor (GPCR) dimers has been reported for an increasing number of cases, but the molecular architecture of signalling units associated to these di...

Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function

Archive ouverte | Baba, Kenkichi | CCSD

International audience. Melatonin stimulates a heteromeric G protein–coupled receptor to modulate the eye’s response to light flashes at night.

Purification and Identification of G Protein- coupled Receptor Protein Complexes under Native Conditions

Archive ouverte | Daulat, Avais, M | CCSD

International audience. G protein-coupled receptors (GPCRs) constitute the largest family of membrane receptors and are of major therapeutic importance. The identification of GPCR-associated proteins is an important...

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