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Interaction between the Elastin Peptide VGVAPG and Human Elastin Binding Protein

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Blanchevoye, Charlotte | Floquet, Nicolas | Scandolera, Amandine | Baud, Stéphanie | Maurice, Pascal | Bocquet, Olivier | Blaise, Sébastien | Ghoneim, Christelle | Cantarelli, Benoît | Delacoux, Frédéric | Dauchez, Manuel | Efremov, Roman, G | Martiny, Laurent | Duca, Laurent | Debelle, Laurent

Edité par CCSD ; American Society for Biochemistry and Molecular Biology -

International audience. Background: The interaction of the peptide VGVAPG with the elastin binding protein is critically involved in aneurysm progression.Results: A molecular model of this interaction is proposed and explored using a site-directed mutagenesis strategy.Conclusion: Three residues, Leu-103, Arg-107, and Glu-137, of elastin binding protein are critical players in this interaction. Significance: Our data now allow the design of antagonists of VGVAPG.

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