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Whole exome sequencing of wild-derived inbred strains of mice improves power to link phenotype and genotype

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Chang, Peter | Kopania, Emily | Keeble, Sara | Sarver, Brice | Larson, Erica | Orth, Annie | Belkhir, Khalid | Boursot, Pierre | Bonhomme, François | Good, Jeffrey | Dean, Matthew

Edité par CCSD ; Springer Verlag -

International audience. stop codons. Simulations demonstrate that the higher density of genetic variation in the Montpellier strains provides increased power for quantitative genetic studies. Inasmuch as the power to connect genotype to phenotype depends on genetic variation, it is important to incorporate these additional genetic strains into future research programs. Illumina sequencing data are available in NCBI under the BioProject PRJNA326865.

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