Afficher la couverture 'Targeting the Tetraspanins with Monoclonal Antibodies in Oncology: Focus on Tspan8/Co-029 | Bonnet, Mathilde' en grand format
/5

0 avis

Targeting the Tetraspanins with Monoclonal Antibodies in Oncology: Focus on Tspan8/Co-029

Archive ouverte

Bonnet, Mathilde | Maisonial-Besset, Aurélie | Zhu, Yingying | Witkowski, Tiffany | Roche, Gwenaelle | Boucheix, Claude | Greco, Céline | Degoul, Françoise

Edité par CCSD ; MDPI -

International audience. Tetraspanins are exposed at the surface of cellular membranes, which allows for the fixation of cognate antibodies. Developing specific antibodies in conjunction with genetic data would largely contribute to deciphering their biological behavior. In this short review, we summarize the main functions of Tspan8/Co-029 and its role in the biology of tumor cells. Based on data collected from recently reported studies, the possibilities of using antibodies to target Tspan8 in immunotherapy or radioimmunotherapy approaches are also discussed.

Suggestions

Du même auteur

Tetraspanin 8 (TSPAN 8) as a potential target for radio-immunotherapy of colorectal cancer

Archive ouverte | Maisonial-Besset, Aurelie | CCSD

International audience. Tetraspanin 8 (TSPAN8) overexpression is correlated with poor prognosis in human colorectal cancer (CRC). A murine mAb Ts29.2 specific for human TSPAN8 provided significant efficiency for imm...

Multi-factorial modulation of colorectal carcinoma cells motility - partial coordination by the tetraspanin Co-029/tspan8

Archive ouverte | Zhu, Yingying | CCSD

International audience. Colorectal carcinoma cells Isreco1 display an ability to migrate controlled by a complex set of signals issued from the membrane. By comparing cells infected by mycoplasmas and mycoplasmas fr...

The Tetraspanin Tspan8 Associates with Endothelin Converting Enzyme ECE1 and Regulates Its Activity

Archive ouverte | Zhu, Yingying | CCSD

International audience. Tetraspanins are cell surface proteins that induce the compartmentalization of molecules with receptor, signaling, or enzymatic properties in microdomains that could serve the integration of ...

Chargement des enrichissements...