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CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity

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Opazo, Patricio | Viana da Silva, Silvia | Carta, Mario | Breillat, Christelle | Coultrap, Steven | Grillo-Bosch, Dolors | Sainlos, Matthieu | Coussen-Choquet, Françoise | Bayer, K. Ulrich | Mulle, Christophe | Choquet, Daniel

Edité par CCSD ; Elsevier Inc -

International audience. In Brief Opazo et al. show that oligomeric and synaptotoxic forms of the Ab peptide trigger the rapid activation of CaMKII throughout the neuron. They find that aberrant CaMKII activation leads to deficits in long-term potentiation and ultimately synaptic loss via the destabilization of AMPA receptors.

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