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Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration

Archive ouverte | Levy, Olivier | CCSD

International audience. Physiologically, the retinal pigment epithelium (RPE) expresses immunosuppressive signals such as FAS ligand (FASL), which prevents the accumulation of leukocytes in the subretinal space. Age...

Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation

Archive ouverte | Calippe, Bertrand | CCSD

International audience. Variants of the CFH gene, encoding complement factor H (CFH), show strong association with age-related macular degeneration (AMD), a major cause of blindness. Here, we used murine models of A...

P2rx7 deficiency does not alter subretinal Mononuclear Phagocytes recruitment nor photoreceptor loss 4 days after retinal detachment.

Archive ouverte | Hu, Shulong J | CCSD

Referenced in J Neurosci as URL. To investigate whether P2rx7 inhibition prevented photoreceptor toxicity of C57BL/6J-Mononucelar phagocytes (MPs), we submitted C57BL/6J and P2rx7-/- mice to experimental retinal de...

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