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Antibodies Preventing the Interaction of Tissue-Type Plasminogen Activator With N-Methyl- d -Aspartate Receptors Reduce Stroke Damages and Extend the Therapeutic Window of Thrombolysis

Archive ouverte | Macrez, Richard | CCSD

International audience. Background and Purpose— Tissue-type plasminogen activator (tPA) is the only drug approved for the acute treatment of ischemic stroke but with two faces in the disease: beneficial fibrinolysis...

ADAMTS proteoglycanases in the physiological and pathological central nervous system.

Archive ouverte | Lemarchant, Sighild | CCSD

International audience. : ADAMTS-1, -4, -5 and -9 belong to 'a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)' family and more precisely to the proteoglycanases subgroup based on their common ...

Age and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact.

Archive ouverte | Roussel, Benoit, D | CCSD

International audience. Recombinant tissue-type plasminogen activator (tPA) is the fibrinolytic drug of choice to treat stroke patients. However, a growing body of evidence indicates that besides its beneficial thro...

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