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Cues predicting drug or food reward restore morphine-induced place conditioning in mice lacking delta opioid receptors

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Le Merrer, Julie | Faget, Lauren | Matifas, Audrey | Kieffer, Brigitte, L.

Edité par CCSD ; Springer Verlag -

International audience. The exact role of delta opioid receptors in drug-induced conditioned place preference (CPP) remains debated. Under classical experimental conditions, morphine-induced CPP is decreased in mice lacking delta opioid receptors (Oprd1 (-/-)). Morphine self-administration, however, is maintained, suggesting that drug-context association rather than drug reward is deficient in these animals.

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