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A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease

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Caussy, C. | Tripathi, A. | Humphrey, G. | Bassirian, S. | Singh, S. | Faulkner, C. | Bettencourt, R. | Rizo, E. | Richards, L. | Xu, Z. Z. | Downes, M. R. | Evans, R. M. | Brenner, D. A. | Sirlin, C. B. | Knight, R. | Loomba, R.

Edité par CCSD ; Nature Publishing Group -

International audience. The presence of cirrhosis in nonalcoholic-fatty-liver-disease (NAFLD) is the most important predictor of liver-related mortality. Limited data exist concerning the diagnostic accuracy of gut-microbiome-derived signatures for detecting NAFLD-cirrhosis. Here we report 16S gut-microbiome compositions of 203 uniquely well-characterized participants from a prospective twin and family cohort, including 98 probands encompassing the entire spectrum of NAFLD and 105 of their first-degree relatives, assessed by advanced magnetic-resonance-imaging. We show strong familial correlation of gut-microbiome profiles, driven by shared housing. We report a panel of 30 features, including 27 bacterial features with discriminatory ability to detect NAFLD-cirrhosis using a Random Forest classifier model. In a derivation cohort of probands, the model has a robust diagnostic accuracy (AUROC of 0.92) for detecting NAFLD-cirrhosis, confirmed in a validation cohort of relatives of proband with NAFLD-cirrhosis (AUROC of 0.87). This study provides evidence for a fecal-microbiome-derived signature to detect NAFLD-cirrhosis.

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