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Downregulation of myostatin pathway in neuromuscular diseases may explain challenges of anti-myostatin therapeutic approaches

Archive ouverte | Mariot, Virginie | CCSD

International audience. Abstract Muscular dystrophies are characterized by weakness and wasting of skeletal muscle tissues. Several drugs targeting the myostatin pathway have been used in clinical trials to increase...

Correlation between low FAT1 expression and early affected muscle in facioscapulohumeral muscular dystrophy

Archive ouverte | Mariot, Virginie | CCSD

International audience. OBJECTIVE: Facioscapulohumeral muscular dystrophy (FSHD) is linked to either contraction of D4Z4 repeats on chromosome 4 or to mutations in the SMCHD1 gene, both of which result in the aberra...

Muscle cells of sporadic amyotrophic lateral sclerosis patients secrete neurotoxic vesicles

Archive ouverte | Le Gall, Laura | CCSD

International audience. Background: The cause of the motor neuron (MN) death that drives terminal pathology in amyotrophic lateral sclerosis (ALS) remains unknown, and it is thought that the cellular environment of ...

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