Structural features in aminoacyl-tRNAs required for recognition by elongation factor Tu.

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Structural features in aminoacyl-tRNAs required for recognition by elongation factor Tu.

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Edité par CCSD ; Wiley -

International audience. In bacterial polypeptide synthesis aminoacyl-tRNA (aa-tRNA) bound to elongation factor Tu (EF-Tu) and GTP is part of a crucial intermediate ribonucleoprotein complex involved in the decoding of messenger RNA. The conformation and topology as well as the affinity of the macromolecules in this ternary aa-tRNA X EF-Tu X GTP complex are of fundamental importance for the nature of the interaction of the complex with the ribosome. The structural elements of aa-tRNA required for interaction with EF-Tu and GTP and the resulting functional implications are presented here.

Langue: en

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