Influence of obesity-related risk factors in the aetiology of glioma

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Disney-Hogg, Linden | Sud, Amit | Law, Philip, J | Cornish, Alex, J | Kinnersley, Ben | Ostrom, Quinn, T | Labreche, Karim | Eckel-Passow, Jeanette, E | Armstrong, Georgina | Claus, Elizabeth, B | Il'Yasova, Dora | Schildkraut, Joellen | Barnholtz-Sloan, Jill | Olson, Sara, H | Bernstein, Jonine, L | Lai, Rose, K | Swerdlow, Anthony | Simon, Matthias | Hoffmann, Per | Nöthen, Markus | Jöckel, Karl-Heinz | Chanock, Stephen | Rajaraman, Preetha | Johansen, Christoffer | Jenkins, Robert, B | Melin, Beatrice | Wrensch, Margaret, R | Sanson, Marc | Bondy, Melissa, L. | Houlston, Richard

Edité par CCSD ; Cancer Research UK -

International audience. BACKGROUND:Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation framework to examine whether obesity-related traits influence glioma risk. This methodology reduces bias from confounding and is not affected by reverse causation.METHODS:Genetic instruments were identified for 10 key obesity-related risk factors, and their association with glioma risk was evaluated using data from a genome-wide association study of 12,488 glioma patients and 18,169 controls. The estimated odds ratio of glioma associated with each of the genetically defined obesity-related traits was used to infer evidence for a causal relationship.RESULTS:No convincing association with glioma risk was seen for genetic instruments for body mass index, waist-to-hip ratio, lipids, type-2 diabetes, hyperglycaemia or insulin resistance. Similarly, we found no evidence to support a relationship between obesity-related traits with subtypes of glioma-glioblastoma (GBM) or non-GBM tumours.CONCLUSIONS:This study provides no evidence to implicate obesity-related factors as causes of glioma.

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