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New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.

Archive ouverte | López-Ramos, Miriam | CCSD

International audience. Protein kinase casein kinase 2 (CK2) is a serine/threonine kinase with evidence of implication in growth dysregulation and apoptosis resistance, making it a relevant target for cancer therapy...

Salicylaldehyde derivatives as new protein kinase CK2 inhibitors.

Archive ouverte | Prudent, Renaud | CCSD

International audience. Protein kinase CK2 is a Ser/Thr kinase, with a constitutive activity, that is considered as a promising target for cancer therapy. The currently available CK2 inhibitors lack the potency and ...

Identification of polyoxometalates as nanomolar noncompetitive inhibitors of protein kinase CK2.

Archive ouverte | Prudent, Renaud | CCSD

International audience. Protein kinase CK2 is a multifunctional kinase of medical importance that is dysregulated in many cancers. In this study, polyoxometalates were identified as original CK2 inhibitors. [P2Mo18O...

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