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Characterization and inhibition of aminopeptidase A by α-mercapto-β-amino acyl dipeptides

Archive ouverte | David, Christelle | CCSD

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Investigation of Subsite Preferences in Aminopeptidase A (EC 3.4.11.7) Led to the Design of the First Highly Potent and Selective Inhibitors of This Enzyme

Archive ouverte | David, Christelle | CCSD

International audience. The study of the physiological roles of the membrane-bound zinc-aminopeptidase A (glutamyl aminopeptidase, EC 3.4.11.7) needs the design of efficient and selective inhibitors of this enzyme. ...

Aminopeptidase A, generating one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, plays a key role in central control of blood pressure.

Archive ouverte | Rozenfeld, Raphael | CCSD

International audience

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