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Tax Protein-induced Expression of Antiapoptotic Bfl-1 Protein Contributes to Survival of Human T-cell Leukemia Virus Type 1 (HTLV-1)-infected T-cells

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Macaire, Héloïse | Riquet, Aurélien | Moncollin, Vincent | Biémont-Trescol, Marie-Claude | Duc Dodon, Madeleine | Hermine, Olivier | Debaud, Anne-Laure | Mahieux, Renaud | Mesnard, Jean-Michel | Pierre, Marlène | Gazzolo, Louis | Bonnefoy, Nathalie | Valentin, Hélène

Edité par CCSD ; American Society for Biochemistry and Molecular Biology -

International audience. Background: Antiapoptotic Bcl-2 proteins are up-regulated in HTLV-1-infected T-cells.Results: Antiapoptotic Bfl-1 protein is regulated by viral Tax and HBZ proteins and is involved in survival of HTLV-1-transformed T-cells.Conclusion: Bfl-1, as well as Bcl-xL, induces resistance to apoptosis in HTLV-1-transformed T-cells.Significance: We provide evidence for Bfl-1 and Bcl-xL as potential therapeutic targets in the treatment of leukemia/lymphoma associated with HTLV-1.

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