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Thiazolylaminomannosides As Potent Antiadhesives of Type 1 Piliated Escherichia coli Isolated from Crohn’s Disease Patients

Archive ouverte | Brument, Sami | CCSD

International audience. Adherent-invasive Escherichia coil (AIEC) have previously been shown to induce gut inflammation in patients with Crohn's disease (CD). We developed a set of mannosides to prevent AIEC attachm...

Oligomannose-Rich Membranes of Dying Intestinal Epithelial Cells Promote Host Colonization by Adherent-Invasive E. coli

Archive ouverte | Dumych, Tetiana | CCSD

International audience. A novel mechanism is revealed by which clinical isolates of adherent-invasive Escherichia coli (AIEC) penetrate into the epithelial cell layer, replicate, and establish biofilms in Crohn's di...

Physiochemical tuning of potent escherichia coli anti-adhesives by microencapsulation and methylene homologation

Archive ouverte | Alvarez-Dorta, Dimitri | CCSD

Thiazolylaminomannosides (TazMan) are FimH antagonists with anti-adhesive potential against adherent-invasive Escherichia coli (AIEC) promoting gut inflammation in patients with Crohn's disease. The lead TazMan is highly potent in...

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