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Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo

Archive ouverte | Rota, Giorgia | CCSD

International audience. In chronic infection and cancer, T cells acquire a dysfunctional state characterized by the expression of inhibitory receptors. In vitro studies implicated the phosphatase Shp-2 downstream of...

The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity

Archive ouverte | Castro, Wilson | CCSD

International audience. Regulatory factor X 7 (Rfx7) is an uncharacterized transcription factor belonging to a family involved in ciliogenesis and immunity. Here, we found that deletion of Rfx7 leads to a decrease i...

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells

Archive ouverte | Niogret, Charlene | CCSD

International audience. The phosphatase Shp-2 was implicated in NK cell development and functions due to its interaction with NK inhibitory receptors, but its exact role in NK cells is still unclear. Here we show, u...

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