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Diagnostic challenge in a series of eleven patients with hyper IgE syndromes

Archive ouverte | Yaakoubi, Roukaya | CCSD

International audience. Hyper IgE syndromes (HIES) is a heterogeneous group of Inborn Errors of Immunity characterized by eczema, recurrent skin and lung infections associated with eosinophilia and elevated IgE leve...

Profound differences in IgE and IgG recognition of micro‐arrayed allergens in hyper‐IgE syndromes

Archive ouverte | Garib, Victoria | CCSD

International audience. BackgroundThe specificities of IgE and IgG for allergen molecules in patients with inborn errors of immunity (IEI) have not been investigated in detail.ObjectiveTo study IgE and IgG antibody ...

Hypomorphic homozygous mutations in phosphoglucomutase 3 (PGM3) impair immunity and increase serum IgE levels.

Archive ouverte | Sassi, Atfa | CCSD

International audience. BACKGROUND: Recurrent bacterial and fungal infections, eczema, and increased serum IgE levels characterize patients with the hyper-IgE syndrome (HIES). Known genetic causes for HIES are mutat...

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