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Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients

Archive ouverte | Magnotti, Flora | CCSD

International audience. Familial Mediterranean fever (FMF) is the most frequent hereditary systemic autoinflammatory syndrome. FMF is usually caused by biallelic mutations in the MEFV gene, encoding Pyrin. Conclusiv...

Geoepidemiology and Immunologic Features of Autoinflammatory Diseases: a Comprehensive Review

Archive ouverte | Jamilloux, Yvan | CCSD

International audience. The knowledge on systemic autoinflammatory disorders (SAID) is expanding rapidly and new signalling pathways are being decrypted. The concept of autoinflammation has been proposed since 1999,...

Mutations in the B30.2 and the central helical scaffold domains of pyrin differentially affect inflammasome activation

Archive ouverte | Chirita, Daria | CCSD

International audience. Abstract Familial Mediterranean Fever (FMF) is the most common monogenic autoinflammatory disorder. FMF is caused by mutations in the MEFV gene, encoding pyrin, an inflammasome sensor. The be...

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