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The RPAP3 C-terminal domain identifies R2TP-like quaternary chaperones

Archive ouverte | Maurizy, Chloé | CCSD

International audience

The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones

Archive ouverte | Maurizy, Chloé | CCSD

International audience. R2TP is an HSP90 co-chaperone that assembles important macro-molecular machineries. Itis composed of an RPAP3-PIH1D1 heterodimer, which binds the two essential AAA+ATPasesRUVBL1/RUVBL2. Here,...

Crystal structure of the RPAP3-PIH1D1 cochaperones complex and regulation of the R2TP-Hsp90 machinery during macromolecular complex assembly

Archive ouverte | Henri, Julien | CCSD

International audience. The Hsp90 molecular chaperone is responsible for the conformational activation and assembly of proteins that are essential for cell signaling and regulation. Many of these client proteins con...

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